HCG 5000iu Lyophilized | Human Chorionic Gonadotropin

Human Chorionic Gonadotropin HCG 5000iu Lyophilized Research Peptide: Advanced Technical & Structural Profile

Product Overview

The HCG 5000iu (Human Chorionic Gonadotropin) lyophilized powder represents a standard of excellence in glycoprotein hormone synthesis, engineered specifically for advanced laboratory investigations, receptor binding assays, and endocrine pathway modeling. As a complex heterodimeric glycoprotein consisting of non-covalently bound alpha and beta subunits, this reference material provides exceptional structural consistency for high-throughput in-vitro protocols. Distributed in robust 5000iu configurations, this pharmaceutical-grade lyophilized solid supports rigorous scientific studies requiring strict purity standards (\ge 98\% verified via High-Performance Liquid Chromatography and Mass Spectrometry).

Structural Characteristics and Biochemical Properties

Molecular Weight: Approximately 36.7 kDa to 37.9 kDa (featuring approximately 31\% carbohydrate content by weight).

Subunit Architecture: Heterodimeric structure comprising a 92-amino-acid \alpha-subunit (common among glycoprotein hormone families) and a 145-amino-acid hormone-specific \beta-subunit.

CAS Number: 9002-61-3

Appearance: White lyophilized solid cake, vacuum-sealed under an inert atmosphere to ensure maximum stability.

Solubility: Fully soluble in sterile water and compatible with standard bacteriostatic buffers for analytical titration.

Mechanism of Action in Experimental Models

In controlled research settings, the primary utility of Human Chorionic Gonadotropin lies in its precise interaction profile across gonadotropin signaling pathways:

1 Luteinizing Hormone/Chorionic Gonadotropin Receptor (LHCGR) Binding: Selectively targets and binds to cell-surface LHCGR complexes on gonadal tissue models, inducing conformational changes and receptor dimerization.

2 cAMP-Dependent Intracellular Signaling: Activates adenylyl cyclase pathways to elevate intracellular cyclic AMP (cAMP) concentrations, driving downstream steroidogenic enzyme activity markers.

3 Endocrine and Cellular Modeling: Utilized in-vitro to study luteinization mechanisms, gonadal cell differentiation dynamics, and reproductive axis regulation models.

Quality Assurance, Handling, and Storage Protocol

Purity Verification: Each individual batch undergoes rigorous third-party analytical testing via HPLC and mass spectrometry, ensuring a verified purity threshold exceeding 98% with complete documentation available via lot-specific Certificates of Analysis.

Lyophilized Storage: Store dry powder at -20•C-in a desiccated, dark environment protected from direct light and moisture exposure.

Reconstitution Guidelines: Reconstitute strictly using sterile bacteriostatic water, introducing the solvent gently down the inner glass wall to maintain structural integrity and avoid mechanical shearing of the glycoprotein structure.

Post-Reconstitution Maintenance: Store reconstituted solutions between 2•C and 8•C, utilizing contents within standard experimental stability windows.