HGH 24iu Lyophilized Powder

HGH 24iu Lyophilized Research Peptide: Advanced Technical & Structural Profile

Product Overview

The HGH 24iu (Somatropin) lyophilized powder represents a standard of excellence in recombinant protein synthesis, engineered specifically for advanced laboratory investigations, receptor binding assays, and endocrine pathway modeling. As a synthetic 191-amino-acid single-chain polypeptide whose structure is identical to endogenous human pituitary growth hormone, this reference material provides exceptional consistency for high-throughput in-vitro protocols. Distributed in robust 24iu configurations, this pharmaceutical-grade lyophilized solid supports rigorous scientific studies requiring strict purity standards (>98% verified via High-Performance Liquid Chromatography and Mass Spectrometry).

Structural Characteristics and Biochemical Properties

Molecular Formula: C990H1528N262O300S7

Molecular Weight: 22,124.77 Da

Amino Acid Sequence: 191-residue single-chain polypeptide identical to endogenous human pituitary hGH, featuring two disulfide bridges (Cys53-Cys165 and Cys182-Cys189).

CAS Number: 12629-01-5

Appearance: White lyophilized solid cake, vacuum-sealed under an inert atmosphere to ensure maximum stability.

Solubility: Fully soluble in sterile water and compatible with standard bacteriostatic buffers for analytical titration.

Mechanism of Action in Experimental Models

In controlled research settings, the primary utility of Somatropin lies in its precise interaction profile across metabolic signaling pathways:

1 Growth Hormone Receptor (GHR) Dimerization: Binds to cell-surface GHR monomers, inducing receptor dimerization and initiating downstream signal transduction cascades.

2 JAK2-STAT5 Signal Transduction: Activates Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5) pathways to regulate target gene transcription.

3 Hepatic IGF-1 Induction: Stimulates hepatic and peripheral tissue synthesis of insulin-like growth factor 1 (IGF-1), driving anabolic and metabolic modeling assays.

4 Lipolytic Regulation: Interacts directly with hormone-sensitive lipase in adipose tissue models to investigate lipid mobilization and energy partitioning.

Quality Assurance, Handling, and Storage Protocol

Purity Verification: Each individual batch undergoes rigorous third-party analytical testing via HPLC and mass spectrometry, ensuring a verified purity threshold exceeding 98\% with complete documentation available via lot-specific Certificates of Analysis.

Lyophilized Storage: Store dry powder at -20^\circ\text{C} in a desiccated, dark environment protected from direct light and moisture exposure.

Reconstitution Guidelines: Reconstitute strictly using sterile bacteriostatic water, introducing the solvent gently down the inner glass wall to maintain structural integrity and avoid mechanical shearing.

Post-Reconstitution Maintenance: Store reconstituted solutions between 2•C and 8•C, utilizing contents within standard experimental stability windows.