Semaglutide 20mg Lyophilized Powder

Semaglutide 20mg Lyophilized Research Peptide: Advanced Technical & Structural Profile

Product Overview

The Semaglutide 20mg lyophilized powder represents a peak benchmark in long-acting glucagon-like peptide-1 (GLP-1) receptor agonist synthesis, engineered specifically for sophisticated laboratory investigations, metabolic pathway modeling, and in-vitro receptor binding assays. As a modified human GLP-1 analogue featuring precise structural enhancements, this reference material provides exceptional kinetic stability and consistency for high-throughput laboratory protocols. Distributed in a secure 20mg configuration, this pharmaceutical-grade lyophilized solid supports rigorous scientific studies requiring strict purity standards (>98% verified via High-Performance Liquid Chromatography and Mass Spectrometry).

Structural Characteristics and Biochemical Properties

Molecular Formula: C187H291N45O59

Molecular Weight: 4,113.58 Da

CAS Number: 910463-68-2

Amino Acid Sequence Modification: Modified human GLP-1(7-37) peptide featuring an aminoisobutyric acid (Aib) substitution at position 8, attachment of a C18 fatty diacid chain via a hydrophilic spacer at lysine 26, and an omitted C-terminal residue.

Appearance: White lyophilized solid cake, vacuum-sealed under an inert atmosphere to ensure maximum integrity.

Solubility: Compatible with standard aqueous bacteriostatic buffers for analytical titration.

Mechanism of Action in Experimental Models

In controlled research settings, the primary utility of Semaglutide lies in its selective interaction profile across metabolic signaling pathways:

1 GLP-1 Receptor Agonism: Selectively binds to and activates cell-surface GLP-1 receptors to evaluate cellular signaling dynamics and adenylate cyclase stimulation.

2 Albumin Binding and Extended Kinetics: Utilizes an attached fatty diacid chain to reversibly bind to plasma albumin, protecting the peptide from enzymatic degradation by dipeptidyl peptidase-4 (DPP-4) and extending its half-life in comparative modeling.

3 Metabolic Pathway Investigation: Deployed in cellular assays to study insulinotropic pathways, glycemic parameter modeling, and central nervous system appetite-regulating neuronal circuitry.

Quality Assurance, Handling, and Storage Protocol

Purity Verification: Each individual batch undergoes rigorous third-party analytical testing via HPLC and mass spectrometry, ensuring a verified purity threshold exceeding 98\% with complete documentation available via lot-specific Certificates of Analysis.

Lyophilized Storage: Store dry powder at -20^\circ\text{C} in a desiccated, dark environment protected from direct light and moisture exposure.

Reconstitution Guidelines: Reconstitute strictly using sterile bacteriostatic water, introducing the solvent gently down the inner glass wall to maintain structural integrity and avoid mechanical shearing.

Post-Reconstitution Maintenance: Store reconstituted solutions between 2•C and 8•C, utilizing contents within standard experimental stability windows.

Regulatory Notice: This material is supplied strictly for laboratory research, analytical reference, and scientific evaluation purposes only. It is explicitly not approved for human consumption, clinical diagnostic application, or therapeutic administration.