SNAP-8 10mg | Acetyl Octapeptide-3

SNAP-8 10mg Lyophilized Research Peptide: Advanced Technical & Structural Profile

Product Overview

The SNAP-8 10mg (Acetyl Octapeptide-3) lyophilized powder represents an advanced benchmark in synthetic neuropeptide synthesis, engineered specifically for sophisticated laboratory investigations, cellular signaling assays, and SNARE-complex assembly modeling. As an elongated synthetic octapeptide derivative of acetyl hexapeptide-3, this reference material mimics portions of the SNAP-25 protein to support high-throughput in-vitro biochemical protocols. Distributed in a secure 10mg configuration, this pharmaceutical-grade lyophilized solid supports rigorous scientific studies requiring strict purity standards (\ge 98\% verified via High-Performance Liquid Chromatography and Mass Spectrometry).

Structural Characteristics and Biochemical Properties

Molecular Formula: C41H70N16O16S

Molecular Weight: 1,075.16 Da

CAS Number: 868844-74-0

Amino Acid Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (Ac-EEMQRRAD-NH_2), featuring an N-terminal acetyl group and a C-terminal primary amide for enhanced stability.

Appearance: White lyophilized solid cake, vacuum-sealed under an inert atmosphere to ensure maximum integrity.

Solubility: Highly soluble in aqueous solutions and compatible with standard bacteriostatic buffers for precise analytical titration.

Mechanism of Action in Experimental Models

In controlled research settings, the primary utility of SNAP-8 lies in its targeted interaction profile across cellular communication pathways:

1 SNARE-Complex Competitive Modeling: Designed to competitively interact with the SNARE protein complex, disrupting assembly dynamics and vesicle fusion pathways in cellular assays.

2 Neuropeptide Exocytosis Inhibition Studies: Utilized in-vitro to investigate the modulation of catecholamine and neurotransmitter exocytosis mechanisms.

3 Receptor and Protein-Protein Interaction Assays: Acts as a stable reference standard for evaluating peptide-membrane interactions and receptor-ligand binding kinetics relative to endogenous SNAP-25 fragments.

Quality Assurance, Handling, and Storage Protocol

Purity Verification: Each individual batch undergoes rigorous third-party analytical testing via HPLC and mass spectrometry, ensuring a verified purity threshold exceeding 98\% with complete documentation available via lot-specific Certificates of Analysis.

Lyophilized Storage: Store dry powder at -20^\circ\text{C} in a desiccated, dark environment protected from direct light, moisture exposure, and oxidative stress.

Reconstitution Guidelines: Reconstitute strictly using sterile bacteriostatic water, introducing the solvent gently down the inner glass wall to maintain structural integrity and avoid mechanical shearing.

Post-Reconstitution Maintenance: Store reconstituted solutions between 2•C and 8•C, utilizing contents within standard experimental stability windows.

Regulatory Notice: This material is supplied strictly for laboratory research, analytical reference, and scientific evaluation purposes only. It is explicitly not approved for human consumption, clinical diagnostic application, cosmetic manufacturing, or therapeutic administration.