Tesamorelin 20mg Lyophilized Powder

Tesamorelin 20mg Lyophilized Research Peptide: Advanced Technical & Structural Profile

Product Overview

The Tesamorelin 20mg lyophilized powder represents an advanced benchmark in growth hormone-releasing hormone (GHRH) analogue synthesis, engineered specifically for sophisticated laboratory investigations, receptor binding assays, and endocrine pathway modeling. As a synthetic 44-amino-acid peptide analogue featuring an N-terminal trans-3-hexenoic acid addition, this reference material replicates endogenous GHRH structural properties while offering superior resistance to enzymatic degradation. Distributed in robust 20mg configurations, this pharmaceutical-grade lyophilized solid supports high-throughput in-vitro protocols requiring strict purity standards (>99% verified via High-Performance Liquid Chromatography and Mass Spectrometry).

Structural Characteristics and Biochemical Properties

Molecular Formula: C221H366N72O67S

Molecular Weight: 5,135.97 Da

Amino Acid Sequence: trans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH_2

CAS Number: 218949-48-5

Appearance: White lyophilized solid cake, vacuum-sealed under an inert atmosphere to ensure maximum stability.

Solubility: Soluble in aqueous solutions and compatible with standard bacteriostatic diluents for precise analytical titration.

Mechanism of Action in Experimental Models

In controlled research settings, the primary utility of Tesamorelin lies in its selective interaction profile across pituitary signaling pathways:

1 GHRH Receptor Binding: Selectively targets and activates growth hormone-releasing hormone receptors located on the anterior pituitary gland's somatotroph cells.

2 Endogenous Secretion Stimulation: Evaluates intracellular cyclic AMP (cAMP) signaling cascades, mimicking natural pulsatile hormonal release patterns in experimental models.

3 Metabolic and Somatotropic Modeling: Used in cellular assays to investigate lipolytic pathways, nitrogen retention, and protein synthesis kinetics relative to growth axis regulation.

The addition of the hydrophobic trans-3-hexenoic acid group at the N-terminus significantly enhances metabolic stability compared to native GHRH sequences, making it an ideal reference standard for extended kinetic assays.

Quality Assurance, Handling, and Storage Protocol

Purity Verification: Each individual batch undergoes rigorous third-party analytical testing via HPLC and mass spectrometry, ensuring a verified purity threshold exceeding 99% with complete documentation available via lot-specific Certificates of Analysis.

Lyophilized Storage: Store dry powder at -20•C in a desiccated, dark environment protected from direct light and moisture exposure.

Reconstitution Guidelines: Reconstitute strictly using sterile bacteriostatic water, introducing the solvent gently down the inner glass wall to maintain structural integrity and avoid mechanical shearing of the peptide backbone.

Post-Reconstitution Maintenance: Store reconstituted solutions between 2•C and 8•C, utilizing contents within standard experimental stability windows (typically within 14 days).

Regulatory Notice: This material is supplied strictly for laboratory research, analytical reference, and scientific evaluation purposes only. It is explicitly not approved for human consumption, clinical diagnostic application, veterinary use, or therapeutic administration.